Pharmacokinetics of halothane in the dog. Comparison of theory and measurement in individuals.

After surgical preparation under pentobarbitone anaesthesia seven dogs of mean body weight 31 kg were ventilated with 1% halothane for 80 min. At 1, 2, 5, 10, 20, 40 and 80 min after the start of the halothane administration blood samples were taken from the femoral artery and pulmonary artery and from a cerebral, a renal and a femoral vein. At 80 min a biopsy sample of skeletal muscle (psoas) was taken.

Organ weights in the dog.

The masses of the major organs in eight large dogs, mostly of alsatian type, which had been subjected to about 8 h anaesthesia and surgery, were determined by post mortem weighing. The organ masses as percentage of the total body mass (29.6 +/- 6.