PALB2 germline mutations in a multi-gene panel testing cohort of 1905 breast-ovarian cancer patients in Argentina.

Purpose: PALB2 variants have been scarcely described in Argentinian and Latin-American reports. In this study, we describe molecular and clinical characteristics of PALB2 mutations found in multi-gene panels (MP) from breast-ovarian cancer (BOC) families in different institutions from Argentina.

Methods: We retrospectively identified PALB2 pathogenic (PV) and likely pathogenic (LPV) variants from a cohort of 1905 MP results, provided by one local lab (Heritas) and SITHER (Hereditary Tumor Information System) public database.

3d-SPADE: Significance evaluation of spatio-temporal patterns of various temporal extents.

The Spike Pattern Detection and Evaluation (SPADE) analysis is a method to find reoccurring spike patterns in parallel spike train data, and to determine their statistical significance. Here we introduce an extension of the original statistical testing procedure which explicitly accounts for the temporal duration of the patterns. The extension improves the performance in the presence of patterns with different durations, as here demonstrated by application to various synthetic data.

Reproducible Neural Network Simulations: Statistical Methods for Model Validation on the Level of Network Activity Data.

Computational neuroscience relies on simulations of neural network models to bridge the gap between the theory of neural networks and the experimentally observed activity dynamics in the brain. The rigorous validation of simulation results against reference data is thus an indispensable part of any simulation workflow. Moreover, the availability of different simulation environments and levels of model description require also validation of model implementations against each other to evaluate their equivalence.

Methods for identification of spike patterns in massively parallel spike trains.

Temporally, precise correlations between simultaneously recorded neurons have been interpreted as signatures of cell assemblies, i.e., groups of neurons that form processing units.