Publications by authors named "P Puerta-Alcalde"
Article Synopsis
- The study aimed to evaluate whether extended infusions (EI) of β-lactam antibiotics are more effective than intermittent infusions (II) in treating febrile neutropenia, a condition common in patients receiving chemotherapy and stem cell transplants.
- In a clinical trial involving 150 patients from four Spanish hospitals, those receiving EI experienced a slightly lower success rate at day 5 compared to those on II (50.6% vs. 63.0%), although not statistically significant.
- The research concluded that routine use of EI for β-lactams in this patient group is not supported, suggesting the need for further studies to address the diverse clinical aspects of febrile neutropenia.
We appreciate the interest and reflections of Paranhos-Baccalà and colleagues in our recent article published in [...
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- The study analyzed the occurrence of multidrug-resistant (MDR) bacteria in solid cancer patients with bloodstream infections (BSIs) over 25 years, revealing a significant rise in MDR strains, especially ESBL-producing bacteria.
- Among 6,117 BSI episodes, Gram-negative bacilli (GNB) were the most prevalent, and 24.8% of patients received inappropriate empiric antibiotic treatment (IEAT), which correlated with higher mortality rates.
- Risk factors for MDR BSIs included prior antibiotic use, infections occurring during treatment, and specific infection sources, highlighting the need for improved risk assessment and careful antibiotic prescribing to enhance patient outcomes.
Chimeric Antigen Receptor T-Cell Postinfusion Fever: Infection Profile, Clinical Parameters, and Biomarkers Trends to Assist Antibiotic Stewardship.
Open Forum Infect Dis
July 2024
Background: This study aimed to describe documented infections associated with postinfusion fever after CAR T-cell therapy and to evaluate daily changes in vital signs, laboratory results, and the National Early Warning Score (NEWS) in patients with and without confirmed bacterial infections following fever onset, with the objective of assisting in antibiotic stewardship.
Methods: This was a retrospective, observational study including all consecutive adult patients who received CAR T-cell therapy. Documented infection in the first fever episode after infusion, and clinical and analytic trend comparison of patients with bacterial documented infections and those without documented infections, are described.
Corrigendum to "Safety and effectiveness of isavuconazole in real-life non-neu tropenic patients" [International Journal of Infectious Diseases 144 (2024) 107070].
Int J Infect Dis
September 2024