Publications by authors named "P Puente"
Article Synopsis
- Most ovarian cancer patients develop resistance to chemotherapy within five years, highlighting the need to better understand the tumor microenvironment (TME) and its effect on drug response.
- Researchers created a 3D tumor-on-a-chip model with multiple chambers to mimic the TME and study how it influences drug resistance, using various cell combinations to explore different interactions.
- The study found that the presence of cancer-associated fibroblasts (CAFs) increased drug resistance in ovarian cancer cells, but this could be mitigated using therapies targeting the extracellular matrix, suggesting new avenues for treatment.
Article Synopsis
- - KRAS mutations are prevalent in lung adenocarcinoma among Black Americans, leading to the exploration of Polyisoprenylated Cysteinyl amide Inhibitors (PCAIs) as potential therapies to disrupt hyperactive G-protein signaling caused by mutated RAS proteins.
- - Among 17 PCAIs tested, NSL-YHJ-2-27 and NSL-YHJ-2-46 demonstrated significant potency in affecting KRAS-mutated lung cancer cells, with EC50 values of 2.7 μM and 3.3 μM, and notable changes in MAPK pathway enzyme phosphorylation.
- - Treatment with these PCAIs led to decreased levels of key G-proteins linked to cell migration
Historical seroprevalence data for in Spain vary greatly depending on the sampling region owing to different fish consumption habits. As a result of European Regulation (EC) No. 853/2004, the Royal Decree 1420/2006 on the prevention of parasitosis by in fishery products supplied by establishments that serve food to final consumers or to communities came into force in Spain.
View Article and Find Full Text PDFReprogramming of normal fibroblasts into ovarian cancer-associated fibroblasts via non-vesicular paracrine signaling induces an activated fibroblast phenotype.
Biochim Biophys Acta Mol Cell Res
October 2024
Article Synopsis
- Cancer-associated fibroblasts (CAFs) play a crucial role in ovarian cancer progression and drug resistance by altering the extracellular matrix (ECM).
- The study shows that media from ovarian cancer cells can activate normal fibroblasts, leading them to adopt a CAF-like phenotype, enhancing their function and increasing tumor growth.
- Ultimately, this research suggests new strategies for developing targeted therapies against CAFs and ECM-related mechanisms that contribute to chemoresistance in ovarian cancer.