Publications by authors named "P Pour"
Background: Autophagy plays a crucial role in modulating the proliferation of cancer diseases. However, the application of Naringenin (Nar), a compound with potential benefits against these diseases, has been limited due to its poor solubility and bioavailability.
Objective: This study aimed to develop solid lipid nanoparticles (Nar-SLNs) loaded with Nar to enhance their therapeutic impact.
In this study, we evaluated the greenness and whiteness scores for microextraction techniques used in therapeutic drug monitoring. Additionally, the cons and pros of each evaluated method and their impacts on the provided scores are also discussed. The Analytical Greenness Sample Preparation metric tool and white analytical chemistry principles are used for related published works (2007-2023).
View Article and Find Full Text PDFGout, characterized by elevated uric acid levels, is a common inflammatory joint disease associated with pain, joint swelling, and bone erosion. Existing treatments for gout often result in undesirable side effects, highlighting the need for new, safe, and cost-effective anti-gout drugs. Natural products, including medicinal plants and phytochemicals, have gained attention as potential sources of anti-gout compounds.
View Article and Find Full Text PDFBackground And Purpose: Excitotoxicity in nerve cells is a type of neurotoxicity in which excessive stimulation of receptors (such as N-methyl-d-aspartate glutamate receptors (NMDAR)) leads to the influx of high-level calcium ions into cells and finally cell damage or death. This complication can occur after taking some of the plasminogen activators like tissue plasminogen activator and reteplase. The interaction of the kringle2 domain in such plasminogen activator with the amino-terminal domain (ATD) of the NR1 subunit of NMDAR finally leads to excitotoxicity.
View Article and Find Full Text PDFArticle Synopsis
- The study looked into what challenges parents face when trying to get their child diagnosed and treated for juvenile localized scleroderma and systemic sclerosis, which are rare skin conditions.
- Many parents said a big problem was that doctors don’t know enough about these conditions, making it hard to get the right care.
- Even though most families had good education and income, they still faced issues like long wait times, balancing everyday life with healthcare needs, and finding reliable information about their child’s condition.