Publications by authors named "P Pouget"
Cognitive and kinematic markers of ketamine effects in behaving non-human primates.
Eur J Pharmacol
January 2025
Ketamine is widely used to probe cognitive functions relying on the properties of methyl-D-aspartate receptor (NMDAR) synaptic transmission. Numerous works have proved that cognitive performance and adjustments in the decision or perceptual domains are affected after ketamine injection in general circulation of primates. Here, we take advantage of that in the brain stem; horizontal saccade deceleration is controlled by glycine-NMDAR-gated current, while gamma-aminobutyric acid (GABA) current controls vertical deceleration to demonstrate that despite general circulation level manipulation of NMDAR synaptic transmission, the kinematic of the saccade appeared to be in the motor brainstem generator circuit differentially maintained.
View Article and Find Full Text PDFThe relationship between corticospinal excitability and structural integrity in stroke patients.
J Neurol Neurosurg Psychiatry
December 2024
Article Synopsis
- The study investigates the relationship between the structure and function of the corticospinal tract (CST) in predicting motor recovery after a stroke, focusing on patients within a week of experiencing an acute ischemic stroke.
- Involving 70 patients with unilateral upper extremity weakness, it utilized clinical assessment, MRI scans to check CST lesion load, and transcranial magnetic stimulation to gauge motor functions.
- Results show that a high CST lesion load can accurately predict a lack of motor response, and the relationship between CST structure and function varies based on the amplitude of the motor evoked potentials (MEP), influencing recovery patterns in stroke patients.
Article Synopsis
- - The study investigated changes in biological, clinical, and imaging markers in carriers of spinocerebellar ataxia (SCA) types 2 and 7 over one year, focusing on MRI and neurofilament light chain (NfL) levels.
- - It included assessments of neurological function, quality of life, and brain imaging among 15 SCA2 carriers, 15 SCA7 carriers, and 10 control subjects, while noting differences in SARA scores and brain volume from baseline measurements.
- - Results indicated significant brain volume loss and worsening motor function in SCA2 carriers, an increase in SARA scores and thinning of retinal layers in SCA7, highlighting the progressive nature of these at
Equiluminant stimuli help assess the integrity of colour perception and the relationship of colour to other visual features. As a result of individual variation, it is necessary to calibrate experimental visual stimuli to suit each individual's unique equiluminant ratio. Most traditional methods rely on training observers to report their subjective equiluminance point.
View Article and Find Full Text PDFSleep has long been considered as a state of behavioral disconnection from the environment, without reactivity to external stimuli. Here we questioned this 'sleep disconnection' dogma by directly investigating behavioral responsiveness in 49 napping participants (27 with narcolepsy and 22 healthy volunteers) engaged in a lexical decision task. Participants were instructed to frown or smile depending on the stimulus type.
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