Publications by authors named "P Porras-Quesada"

Article Synopsis
  • Prostate cancer (PCa) development is influenced by genetic, environmental, and dietary factors, particularly interactions between chemical exposures and specific genetic variants related to detoxification and DNA repair.
  • A meta-analysis involving over 60,000 participants identified significant associations between certain genetic variants (like SOD2, CAT, PON1, GSTP1, and GSTM1) and an increased risk of PCa, with GSTM1 showing the strongest link.
  • While antioxidant enzymes and detoxifying enzymes are crucial in PCa progression, other risk factors, especially chemical exposures, should also be considered for a comprehensive understanding of PCa risk.
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Background: Approximately 13.8% and 6.1% of coronavirus disease 2019 (COVID-19) patients require hospitalization and sometimes intensive care unit (ICU) admission, respectively.

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Prostate Cancer (PC) is commonly known as one of the most frequent tumors among males. A significant problem of this tumor is that in early stages most of the cases course as indolent forms, so an active surveillance will anticipate the appearance of aggressive stages. One of the main strategies in medical and biomedical research is to find non-invasive biomarkers for improving monitoring and performing a more precise follow-up of diseases like PC.

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Bisphenol A (BPA) is one of the most common endocrine disruptors found in the environment and its harmful health effects in humans and wildlife have been extensively reported One of the main aims of this review was to examine the metabolic pathways of BPA and BPA substitutes and the endocrine disrupting properties of their metabolites. According to the available literature, phase I and phase II metabolic reactions play an important role in the detoxification process of bisphenols (BPs), but their metabolism can also lead to the formation of highly reactive metabolites. The second part of this work addresses the associations between exposure to BPA and its analogues with the alterations in miRNAs expression and the effects of single nucleotide polymorphisms (SNPs).

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