Publications by authors named "P Polykretis"
Alzheimer's disease (AD) is a progressive debilitating neurological disorder representing the most common neurodegenerative disease worldwide. Although the exact pathogenic mechanisms of AD remain unresolved, the presence of extracellular amyloid-β peptide 1-42 (Aβ) plaques in the parenchymal and cortical brain is considered one of the hallmarks of the disease. In this work, we investigated the Aβ fibrillogenesis timeline up to 48 h of incubation, providing morphological and chemo-structural characterization of the main assemblies formed during the aggregation process of Aβ, by atomic force microscopy (AFM) and surface enhanced Raman spectroscopy (SERS), respectively.
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- The global pandemic of COVID-19 led to widespread vaccination even among low-risk groups, raising safety concerns.
- Research indicates that COVID-19 genetic vaccines can distribute throughout the body, including sensitive areas like the heart and brain, potentially triggering harmful immune responses.
- The article emphasizes the need for detailed studies on how these vaccines distribute in the body and the importance of evaluating their risks and benefits based on age.
Article Synopsis
- The current Alzheimer's disease diagnosis relies on various clinical and laboratory tests, but there's a risk of misdiagnosis due to symptom overlap with other dementias.
- A new diagnostic method combines seed amplification assay (SAA) for enhanced sensitivity and surface-enhanced Raman spectroscopy (SERS) for unique specificity to detect brain biomarkers.
- This SAA-SERS technique, aided by machine learning, effectively identifies problematic Aβ oligomers in the cerebrospinal fluid, enabling earlier patient stratification for treatments and clinical trials.
Alzheimer's disease (AD) is the most common neurodegenerative disorder, resulting in memory loss, cognitive decline, bodily function impairment, and finally death. The growing number of people suffering from AD increasingly urges the development of effective early diagnosis and monitoring techniques. Here, we review the most recent developments in the field of Raman-based techniques, which have shown a significant potential in identifying AD by detecting specific biomarkers in biological fluids, as well as in providing fundamental insights into key molecules involved in the disease progression or in the analysis of histological specimens of patients with AD.
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