Publications by authors named "P Poblete"
Article Synopsis
- Mare endometrosis is a problem that makes it hard for horses to have babies because it causes inflammation and damage to the reproductive system.
- Scientists tested if special cells, called mesenchymal stem cells (MSCs), could help by using tiny packages they release called extracellular vesicles (EVs) with important information inside (miRNAs).
- They found that treating MSCs with a specific signal (TGFβ-1) for only 4 hours made them better at fighting the damage, while longer treatment (24 hours) caused more problems, which could help create new treatments for mares with endometrial fibrosis.
Endometrosis in mares is a disease resulting from chronic inflammation characterized by peri glandular fibrosis. There is no effective treatment so far, which opens the door for exploring the use of stem cells as a candidate. Transforming growth factor beta (TGFβ) is crucial for the establishment and progression of fibrosis in mare's endometrosis.
View Article and Find Full Text PDFArticle Synopsis
- - The study assesses how different phases of the oestrus cycle affect inflammation-related gene expression in mare endometrial stromal cells, specifically when exposed to pro-inflammatory cytokines.
- - Cells from the follicular phase showed increased expression of pro-fibrotic genes and miRNAs when treated with certain cytokines, while those from the mid-luteal phase exhibited higher levels of anti-fibrotic miRNAs.
- - The results indicate that pro-inflammatory cytokines can enhance the effects of TGFβ in the follicular phase, leading to significant changes in the molecular landscape relating to inflammation and fibrosis.
Community Emergency Response Teams and disaster volunteerism in Latin America.
J Bus Contin Emer Plan
January 2023
While it may be more common to think of a disaster volunteer as someone from outside the community who comes to assist during times of need, it is important not to forget those members of the community who are well poised to build grassroots resilience when provided with the necessary training and tools. This paper examines the state of disaster volunteerism in Latin America and Spanish-speaking communities in the USA who have been exposed to the Community Emergency Response Team (CERT) programme, with an emphasis on the perceptions of and motivations for grassroots volunteerism from the perspective of both local emergency managers and CERT volunteers. The research team developed an online survey and shared it with active Spanish-speaking emergency management groups throughout the USA, Mexico, Central and South America.
View Article and Find Full Text PDFIntroduction: The submaximal tests are used to measure aerobic capacity and correlate with activities of daily living in chronic patients. The 6-min handbike cycle test (6mhct) was created for nonambulatory subjects, but there are no reference values to quantify and classify the cardiorespiratory fitness of children in this condition.
Objective(s): Generate 6mhct reference values and determine predictive variables in a population of Chilean children between 8 and 13 years old.