Publications by authors named "P Plouvier"
Article Synopsis
- Small RNAs, particularly piRNAs, are essential for male germ cell development, with disruptions leading to male infertility through issues like spermatogenic defects and oligo-astheno-teratozoospermia (OAT).
- The HENMT1 gene is critical for the biogenesis of piRNAs, and its dysfunction can cause severe sperm abnormalities and infertility, as seen in both knockout mice and patients with HENMT1 variants.
- The study aimed to explore the potential for using sperm from two patients with HENMT1 variants in assisted reproductive technologies, but despite thorough analyses and multiple IVF-ICSI attempts, no live births were achieved.
Research Question: Does colorectal endometriosis surgery prior to IVF ± intracytoplasmic sperm injection (ICSI) impact cumulative live birth rates?
Design: This retrospective, monocentric study (Lille University Hospital) was conducted between 1 January 2007 and 31 December 2018. Two groups of patients from the JFIV database were included: a group undergoing IVF±ICSI alone (120 patients, 215 oocyte retrievals), and a group undergoing surgery and then IVF±ICSI (69 patients, 109 oocyte retrievals). The mode of management was decided after a multidisciplinary team meeting.
Research Question: How does the typology and effect of pain vary between infertile patients with or without endometriosis during the different stages of the IVF process?
Design: A prospective, monocentric, observational cohort study was conducted at Lille University Hospital between November 2019 and June 2021. The study was proposed to all patients starting an IVF cycle. Pain assessment questionnaires using validated scales (about type of pain, without specific location), were completed by patients at key points during IVF: before starting treatment, at the end of stimulation and on the day of oocyte retrieval.
Article Synopsis
- * Conducted on patients aged 18-43, the study compared two groups: one receiving only oral dydrogesterone and another receiving both dydrogesterone and weekly intramuscular progesterone.
- * Results show no significant difference in ongoing pregnancy rates or other key fertility outcomes between the two groups, suggesting that adding intramuscular injections does not improve IVF success for single fresh blastocyst transfers.
Article Synopsis
- Some studies suggest that women with polycystic ovary syndrome (PCOS) might have a higher risk of miscarriage, but the evidence is not clear-cut.
- This research examined the effects of different endometrial preparation methods (stimulated vs. artificial cycles) on frozen-thawed embryo transfer (FET) outcomes in 134 anovulatory PCOS patients.
- The findings indicated that there were no significant differences in early pregnancy rates, miscarriage rates, or live birth rates between the two preparation methods.