Metacarpophalangeal collateral ligament reconstruction using small intestinal submucosa in an equine model.

Xenogeneic porcine small intestinal submucosa (SIS) is a natural, biodegradable matrix that has been successfully used as a scaffold for repair of tissue defects. The goal of this study was to compare a collateral ligament transection surgically reconstructed with an anchored SIS ligament to a sham-operated control procedure for the correction of joint laxity using an equine model. Ten metacarpophalangeal joints from 10 horses had complete transection of the lateral collateral ligament.

Effects of a p38 MAP kinase inhibitor on bone ingrowth and tissue differentiation in rabbit chambers.

The effects of an oral p38 mitogen-activated protein kinase (MAPK) inhibitor and polyethylene particles separately and together on tissue differentiation in the bone harvest chamber (BHC) in rabbits over a 3-week treatment period were investigated. The harvested tissue was analyzed histomorphometrically for markers of bone formation (percentage of bone area), osteoblasts (alkaline phosphatase staining), and osteoclasts (CD51, the alpha chain of the vitronectin receptor). Polyethylene particles decreased the percentage of bone ingrowth and staining for alkaline phosphatase.

Evaluation of small-intestinal submucosa implants for repair of meniscal defects in dogs.

Objective: To assess the effects of porcine small intestinal submucosa (SIS) implants on the healing of meniscal lesions in dogs.

Animals: 16 adult Greyhounds of both sexes.

Procedure: Unilateral osteotomy was performed at time 0 to disrupt the medial collateral ligament attachment, and two (1 cranial and 1 caudal) 4-mm circular defects were created in the avascular portion of the medial meniscus.

Effects of local infusion of TGFbeta on bone ingrowth in rabbit chambers.

The local delivery of exogenous growth factors may help achieve a stable, long-lasting prosthetic interface around primary and revision joint replacements. This study examines the effects of local infusion of transforming growth factor beta (TGFbeta) in an in vivo model of tissue differentiation within bone. The Drug Test Chamber was implanted in the proximal medial tibial metaphysis of 8 mature rabbits unilaterally.

Naturally occurring extracellular matrix as a scaffold for musculoskeletal repair.

The use of naturally occurring extracellular matrix materials as scaffolds for the repair and regeneration of tissues is receiving increased attention. The present study evaluates the use of the extracellular matrix derived from porcine small intestinal submucosa as a scaffold for anterior cruciate ligament replacement in a goat model. Sixty healthy adult female goats were divided into two equal groups of 30 each.