Publications by authors named "P Pires"
The repurposing of statins as neuroprotective agents and/or anti-brain tumor drugs is limited by challenges in brain bioavailability and systemic off-target effects. Therefore, improved and targeted delivery of statins to the brain is necessary. This study aimed to develop a high-strength liquid formulation of the poorly soluble prodrug simvastatin for intranasal administration, as a strategy to achieve high brain concentrations of the prodrug and/or its active form, tenivastatin.
View Article and Find Full Text PDFIntroduction: Cerebrovascular dysfunction occurs in Alzheimer's disease (AD), impairing hemodynamic regulation. Large conductance Ca-activated K channels (BK) regulate cerebrovascular reactivity and are impaired in AD. BK activity depends on intracellular Ca (Ca sparks) and nitro-oxidative post-translational modifications.
View Article and Find Full Text PDFObjective: to assess the associations between cost-effectiveness analysis' (CEA) methodological characteristics and Incremental Cost-Effectiveness Ratio (ICER) outcomes and conclusions, in biological treatments for asthma.
Study Design And Setting: We included CEAs comparing biological treatments to standard care, in adults with severe asthma. We performed a search in MEDLINE, EMBASE, and Web of Science (Sep 2022).
Article Synopsis
- Acute kidney injury (AKI) occurs in patients after endovascular therapy for acute ischemic stroke, impacting recovery and survival rates.
- A study involving 1150 patients revealed an AKI incidence of 6%, with risk factors including older age, longer treatment times, and lower kidney function.
- AKI significantly correlates with higher mortality rates, emphasizing the need for improved treatment strategies for at-risk patients.