Current and future burden from Lyme disease in Québec as a result of climate change.

Context: Environmental changes will foster the spread of ticks and increase the incidence of Lyme disease in Québec in the coming years. The objective of this study is to estimate the epidemiological and clinical burden and part of the current economic burden of Lyme disease in Québec and to estimate the number of cases expected by 2050.

Methods: Cases of Lyme disease reported in Québec from 2015 to 2019 were used to describe their demographic, geographical and clinical characteristics and the cost of their initial care.

Clinical and Genomic Investigation of an International Ceftriaxone- and Azithromycin-Resistant Shigella sonnei Cluster among Men Who Have Sex with Men, Montréal, Canada 2017-2019.

Multidrug-resistant (MDR) Shigella sonnei have become prevalent among men who have sex with men and have become a global public health concern. From June 2017 to April 2019, 32 men were infected with MDR S. sonnei acquired locally, in Montréal, which was suggestive of an outbreak.

Evaluation of whole-genome sequencing-based subtyping methods for the surveillance of spp. and the confounding effect of mobile genetic elements in long-term outbreaks.

Many public health laboratories across the world have implemented whole-genome sequencing (WGS) for the surveillance and outbreak detection of foodborne pathogens. PulseNet-affiliated laboratories have determined that most single-strain foodborne outbreaks are contained within 0–10 multi-locus sequence typing (MLST)-based allele differences and/or core genome single-nucleotide variants (SNVs). In addition to being a food- and travel-associated outbreak pathogen, most spp.

Invasive group A streptococcal infection outbreaks of type118 in a long-term care facility, and of type 74 in the homeless population, Montréal, Quebec.

Background: Two invasive group A streptococcus (iGAS) infection outbreaks occurred in Montreal in 2016 and 2017; one in a long-term care facility (type118) and one in the community, primarily involving homeless people (type74).

Objective: To describe two recent iGAS outbreaks in Montréal and highlight the challenges in dealing with these outbreaks and the need to tailor the public health response to control them.

Methodology: All cases of iGAS were investigated and the isolates were sent to the laboratory fortyping.

Genetic Mechanisms behind the Spread of Reduced Susceptibility to Azithromycin in Strains Isolated from Men Who Have Sex with Men in Québec, Canada.

We analyzed 254 species isolates collected in Québec, Canada, during 2013 and 2014. Overall, 23.6% of isolates showed reduced susceptibility to azithromycin (RSA) encoded by (11.