Publications by authors named "P Petzelbauer"
Article Synopsis
- This study investigates the diversity of cancer-associated fibroblasts (CAFs) in various skin cancers, including basal cell carcinoma, squamous cell carcinoma, and melanoma, using advanced analysis techniques.
- Researchers identify three CAF subtypes: myofibroblast-like RGS5+ CAFs, matrix CAFs (mCAFs), and immunomodulatory CAFs (iCAFs), noting that their patterns change with tumor severity.
- The study suggests that targeting specific CAF subtypes could improve the effectiveness of immunotherapy in treating skin cancers, as these cells play distinct roles in tumor progression and immune responses.
The development of keratinocytic skin tumors, presumably attributable to paradoxical activation of the MAPK pathway, represents a relevant side effect of targeted therapies with BRAF inhibitors (BRAFis). The role of cutaneous papillomavirus infection in BRAFi-associated skin carcinogenesis, however, is still inconclusive. Employing the Mus musculus papillomavirus 1 (MmuPV1) skin infection model, the impact of BRAFis and UVB exposure on papillomavirus induced skin tumorigenesis was investigated in immunocompetent FVB/NCrl mice.
View Article and Find Full Text PDFNeutrophil extracellular traps (NETs) are implicated in the pathogenesis of abdominal aortic aneurysm (AAA), located in adventitia and intraluminal thrombus. We compared the therapeutic potential of targeting upstream or downstream effector molecules of NET formation in 2 murine AAA models based on angiotensin II or peri-adventitial elastase application. In both models, NETs were detected in formed aneurysms at treatment start.
View Article and Find Full Text PDFFAM3C/ILEI is an important cytokine for tumor progression and metastasis. However, its involvement in inflammation remains elusive. Here, we show that ILEI protein is highly expressed in psoriatic lesions.
View Article and Find Full Text PDFIntroduction: The implications of infiltrative compared to non-infiltrative growth of cutaneous basal cell carcinoma (BCC) on the tumor stroma and immune cell landscape are unknown. This is of clinical importance, because infiltrative BCCs, in contrast to other BCC subtypes, are more likely to relapse after surgery and radiotherapy.
Materials And Methods: This descriptive cross-sectional study analyzed 38 BCCs collected from 2018 to 2021.