Screening and management of sleep disorders in patients with fibromyalgia syndrome: a French multicentred, prospective, observational study protocol (FIBOBS).

Introduction: Sleep disorders are still often underestimated in patient care management even though they are present in the criteria of the American College of Rheumatology for the diagnosis of fibromyalgia syndrome (FMS). The objective of this study will be to assess the current situation of sleep disorders in patients with FMS in France and to estimate its prevalence.

Methods And Analysis: The FIBOBS study is a multicentred, prospective, observational trial performed by 46 specialised chronic pain structures in France.

Large metallicity variations in the Galactic interstellar medium.

The interstellar medium (ISM) comprises gases at different temperatures and densities, including ionized, atomic and molecular species, and dust particles. The neutral ISM is dominated by neutral hydrogen and has ionization fractions of up to eight per cent. The concentration of chemical elements heavier than helium (metallicity) spans orders of magnitudes in Galactic stars, because they formed at different times.

River network alteration of C-N-P dynamics in a mesoscale agricultural catchment.

The majority of freshwater ecosystems worldwide suffer from eutrophication, particularly because of agriculture-derived nutrient sources. In the European Union, a discrepancy exists between the scale of regulatory assessment and the size of research catchments. The Water Framework Directive sets water quality objectives at the mesoscale (50-500 km), a scale at which both hillslope and in-stream processes influence carbon (C), nitrogen (N) and phosphorus (P) dynamics.