A deep intronic recurrent CHEK2 variant c.1009-118_1009-87delinsC affects pre-mRNA splicing and contributes to hereditary breast cancer predisposition.

Germline CHEK2 pathogenic variants confer an increased risk of female breast cancer (FBC). Here we describe a recurrent germline intronic variant c.1009-118_1009-87delinsC, which showed a splice acceptor shift in RNA analysis, introducing a premature stop codon (p.

Inkjet-printed high-performance and mechanically flexible organic photodiodes for optical wireless communication.

Emerging areas such as the Internet of Things (IoT), wearable and wireless sensor networks require the implementation of optoelectronic devices that are cost-efficient, high-performing and capable of conforming to different surfaces. Organic semiconductors and their deposition via digital printing techniques have opened up new possibilities for optical devices that are particularly suitable for these innovative fields of application. In this work, we present the fabrication and characterization of high-performance organic photodiodes (OPDs) and their use as an optical receiver in an indoor visible light communication (VLC) system.

Experimental multi-user VLC system using non-orthogonal multi-band CAP modulation.

This paper provides experimental results for a multi-user visible light communications system using multi-band carrier-less amplitude and phase (m-CAP) modulation scheme. We optimize the system performance by adapting pulse shaping filter parameters, subcarrier spacing and allocating different baud rates to individual sub-bands called allocated m-CAP (Am-CAP). We show that a maximal system data rate of ∼468 Mb/s for four users can be supported while gaining higher flexibility for optimization and the same or lower computational complexity compared with the conventional m-CAP scheme.

Visible light communications: increasing data rates with polarization division multiplexing.

In this Letter, we propose a new configuration for visible light communication systems, which results in doubling of the data rate due to the use of polarization division multiplexing. As light-emitting diodes are unpolarized incoherent light sources, we isolate both the perpendicular and parallel modes for independent modulation. For the first time, to the best of our knowledge, we show that it is possible to transmit and successfully recover two separate orthogonal frequency division multiplexing (OFDM) signals on each polarization (pol-OFDM).