Publications by authors named "P Perez Porras"
The International Molecular Exchange Consortium (IMEx) has evolved into a vital partnership of open resources dedicated to curating molecular interaction data from the scientific literature. This consortium, which includes IntAct, MINT, MatrixDB, and DIP, is a collaborative effort with a central mission of aggregating detailed molecular interaction experimental evidence in a machine-readable format, supported by controlled vocabularies and standard ontologies. The IntAct molecular interaction database (www.
View Article and Find Full Text PDFIn recent years, a huge amount of data on ncRNA interactions has been described in scientific papers and databases. Although considerable effort has been made to annotate the available knowledge in public repositories, there are still significant discrepancies in how different resources capture and interpret data on ncRNA functional and physical associations. In the present paper, we present a collection of microRNA-mRNA interactions annotated from the scientific literature following recognized standard criteria and focused on microRNAs, which regulate genes associated with rare diseases as a case study.
View Article and Find Full Text PDFRare genetic diseases affect millions, and identifying causal DNA variants is essential for patient care. Therefore, it is imperative to estimate the effect of each independent variant and improve their pathogenicity classification. Our study of 140 214 unrelated UK Biobank (UKB) participants found that each of them carries a median of 7 variants previously reported as pathogenic or likely pathogenic.
View Article and Find Full Text PDFArticle Synopsis
- Interacting proteins often serve similar functions, affecting the same traits in organisms, and analysis of interaction networks helps identify genes associated with various traits.
- Through network-based analysis of 1,002 human traits, researchers were able to recover known disease genes and drug targets, revealing that certain traits may share genetic processes.
- The study identified 73 pleiotropic gene modules related to multiple traits, especially those involved in protein ubiquitination and RNA processing, and demonstrated their relevance in understanding diseases and potential drug repurposing.
Background: Pre-procedural COVID-19 testing in patients scheduled for elective cases have become routine to reduce the risk of COVID-19 exposure and pulmonary complications related to perioperative COVID-19 infection, and to reduce the use of specific hospital resources among other reasons. This study evaluates the efficacy of universal COVID-19 testing for elective procedures.
Methods: Single institution retrospective observational study from July 2020 through August 2021.