Publications by authors named "P Pathipvanich"
Background: Mannose-binding lectin (MBL) plays a pivotal role in innate immunity; however, its impact on susceptibility to opportunistic infections (OIs) has not yet been examined in a natural history cohort of people living with HIV/AIDS.
Methods: We used archived samples to analyze the association between MBL expression types and risk of major OIs including Pneumocystis jirovecii pneumonia (PCP), cryptococcosis, talaromycosis, toxoplasmosis, and tuberculosis in a prospective cohort in Northern Thailand conducted from 1 July 2000 to 15 October 2002 before the national antiretroviral treatment programme was launched.
Results: Of 632 patients, PCP was diagnosed in 96 (15.
Article Synopsis
- Despite the availability of anti-retroviral therapy (ART) for HIV+ pregnant mothers, over 43,000 babies still get infected each year, making it crucial to study the factors that contribute to mother-to-child transmission (MTCT) of HIV.
- A study in Thailand found that HIV-negative infants had significantly higher levels of Env V3-specific IgG and neutralizing antibodies in their plasma compared to HIV-positive infants, indicating a protective role for these antibodies against transmission.
- However, higher levels of these same antibodies in mothers were associated with an increased risk of MTCT, suggesting a complex relationship between maternal and infant immune responses in understanding HIV transmission dynamics.
Objectives: The risk of kidney dysfunction on the WHO recommended first line regimens containing tenofovir disoproxil fumarate (TDF) without protease inhibitors (PI) remains unclear in Asian patients, especially those with low body weight.
Methods: Using data collected in a multicenter clinical trial in Thailand and proportional hazard regression models, we compared the risk of a >25% estimated glomerular filtration rate (eGFR) reduction in HIV naïve patients initiating TDF or zidovudine (AZT) containing non-PI regimen.
Results: Of 640 patients included in the analysis, 461 (72%) received a TDF-containing regimen for a median 6.
High subsequent and recurrent sexually transmitted infection prevalence among newly diagnosed HIV-positive Thai men who have sex with men and transgender women in the Test and Treat cohort.
Int J STD AIDS
February 2019
We determined subsequent and recurrent sexually transmitted infections (STIs) among men who have sex with men (MSM) and transgender women (TGW) in the Test and Treat cohort. Thai MSM and TGW adults with previously unknown HIV status were enrolled and tested for HIV. Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and syphilis were tested at baseline, month 12, and month 24 to identify subsequent STIs (any STIs diagnosed after baseline) and recurrent STIs (any subsequent STIs diagnosed among those with positive baseline STIs).
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