Efficacy and safety of fixed dose combination of Sitagliptin, metformin, and pioglitazone in type 2 Diabetes (IMPACT study): a randomized controlled trial.

Background: Due to the progressive decline in β-cell function, it is often necessary to utilize multiple agents with complementary mechanisms of action to address various facets and achieve glycemic control. Thus, this study aimed to evaluate the efficacy and safety of a fixed-dose combination (FDC) of metformin/sitagliptin/pioglitazone (MSP) therapy vs. metformin/sitagliptin (MS) in type 2 diabetes mellitus (T2DM).

Harnessing the benefits of yoga for myositis, muscle dystrophies, and other musculoskeletal disorders.

The recent global increase in popularity of home-based yoga, an ancient Indian technique practiced for thousands of years, has translated into its use as a complementary therapy for a multitude of ailments. This review aims to examine the published literature regarding the effects of yoga therapy on systemic chronic diseases; in particular on the inflammatory myopathies (IMs) and other muscle disorders.Despite the fact that the evidence base for yoga in inflammatory myositis is in its infancy, collateral results in other disorders such as muscular dystrophies are promising.

Motor and cognitive testing of bone marrow transplant patients after chemoradiotherapy.

Assessment of cognitive and motor performance of bone marrow transplant patients prior to, during, and following intensive toxic chemoradiotherapy may provide an important adjunct to measures of physiological and medical status. The present study is an attempt to assess whether, as side-effects, these aggressive treatments result in cognitive performance deficits, and if so, whether such changes recover posttreatment. Measurement of cognitive ability in this situation presents special problems not encountered with one-time tests intended for healthy adults.

[Characterization of the effect of analgesics on the assessment of experimental pain in man. Pethidine and tramadol in a double-blind comparison].

The effect of the opioid analgesics tramadol and pethidine on experimentally induced pain was investigated in a double blind study with healthy volunteers. Using a constant current shocker, compensating the changes of the skin resistance, a constantly increasing pain stimulus was produced. Detection-, pain-, and tolerance-thresholds were assessed before and three times after intravenous injection of either pethidine (1 mg/kg bodyweight), tramadol (2 mg/kg bodyweight) or placebo (NaCl).

Numerosity judgments in peripheral vision: limitations of the cortical magnification hypothesis.

We studied visual numerosity judgments for linear dot arrays with regular spacing under central and off-axis observation conditions. Results indicate that an appropriate increase in stimulus size, as determined by the human cortical magnification factor, may compensate for the retinal inhomogeneity of numerosity judgments. Such a compensation, however, is no longer possible if in the numerosity judgments observers are deprived of the cue of overall dot-array length.