Publications by authors named "P Parize"
Introduction: The increase in the population of immunocompromised patients due to advances in management of end-stage diseases and transplants poses challenges in treating infections caused by multi-drug resistant (MDR) pathogens. Cefiderocol (FDC), a siderophore cephalosporin, has shown efficacy against carbapenem-resistant Gram-negative bacteria.
Methods: This retrospective multicentre study investigated the real-world use of FDC in 114 immunocompromised adults treated for MDR infections in 12 French hospitals (June 2020-November 2023).
Objectives: Catheter removal is recommended in adults with Staphylococcus aureus central-line-associated bloodstream infection (CLABSI) but is controversial in children with long-term central venous catheters (LTCVC). We evaluated the occurrence of catheter salvage strategy (CSS) in children with S. aureus LTCVC-associated CLABSI and assessed determinants of CSS failure.
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- Immunocompromised patients are most at risk for severe COVID-19, and some can shed the SARS-CoV-2 virus for extended periods, ranging from weeks to 9 months.
- A study involving 29 patients with persistent viral shedding and 40 controls identified fever and low lymphocyte counts as significant risk factors, alongside the finding that unvaccinated individuals have a much higher risk of persistent shedding.
- Immunocompromised patients who shed the virus persistently are also at increased risk of hospitalization, invasive aspergillosis (a fungal infection), and death, highlighting the need for regular screenings during viral shedding.