Fatigue-induced modifications to trunk and lower-limb coordination mode during drop vertical jump and sidestep cutting tasks in female handball athletes.

Background: Examining movement patterns in athletic activities is crucial for understanding the mechanisms and contributing factors linked to lower limb injuries, with the knee joint being particularly vulnerable in team sports like handball.

Research Question: How does a handball-specific fatigue protocol affect trunk-knee and hip-knee intersegmental coordination during the drop vertical jump (DVJ) and sidestep cutting maneuver (SCM) in handball players?

Methods: Twenty female handball athletes participated, performing three trials of each task before and after undergoing the fatigue protocol. Using a motion capture system, the trunk, hip, and knee joint angles were recorded in all three planes and time-normalized to 100 % of the stance phase.

Diastereoselective Synthesis of Highly Functionalized γ-Lactams via Ugi Reaction/Michael Addition.

The γ-lactam ring is a prominent feature in medicinal chemistry, and its synthesis has garnered significant interest due to its valuable properties. Among the γ-lactams, 2-oxopyrrolidine-3-carbonitrile derivatives stand out as versatile synthons that can be readily transformed into a variety of other functional groups. In this work, we successfully synthesized highly functionalized 3-cyano-2-pyrrolidinones with moderate to good overall yields using the Ugi reaction followed by intramolecular Michael addition.

Personalized Rehabilitation of Atrophic Customized Subperiosteal Implants.

Severe maxillary atrophy and edentulism can pose a range of challenges in implant planning and oral rehabilitation. Modern dentistry has allowed for a review of the concepts and surgical protocols of subperiosteal implants, presenting them as a solution for the rehabilitation of atrophic maxillary and mandibular bone deficiencies. This study aims to address a series of 3 patients with severe maxillary atrophy, as evidenced by presurgical and postsurgical radiographic images, as well as computer-assisted planning and analysis of patient anatomy for rehabilitation with custom sintered subperiosteal implants.