Publications by authors named "P Pantazopoulos"
Liver fibrosis is a common pathway shared by all forms of progressive chronic liver disease. There is an unmet clinical need for noninvasive imaging tools to diagnose and stage fibrosis, which presently relies heavily on percutaneous liver biopsy. Here we explored the feasibility of using a novel type I collagen-targeted manganese (Mn)-based MRI probe, Mn-CBP20, for liver fibrosis imaging.
View Article and Find Full Text PDFMagnetic order typically emerges due to the short-range exchange interaction between the constituent electronic spins. Recent discoveries have found a crucial role for spin-phonon coupling in various phenomena from optical ultrafast magnetization switching to dynamical control of the magnetic state. Here, we demonstrate theoretically the emergence of a biquadratic long-range interaction between spins mediated by their coupling to phonons hybridized with vacuum photons into polaritons.
View Article and Find Full Text PDFArticle Synopsis
- This study investigated how different gadolinium-based contrast agents (GBCAs) behave in the bodies of healthy rats by looking at their distribution and retention in organs, particularly the kidneys, over time.
- Researchers found that gadolinium levels were significantly higher in the kidney cortex compared to other tissues 17 days after injection, with gadoteridol having the least retention among the agents tested.
- The analysis revealed that while most GBCAs remained largely intact in the kidneys after 52 days, the relationship between imaging signals and gadolinium concentration was weak, highlighting challenges in accurately assessing gadolinium retention using standard MRI techniques.
During fibroproliferation, protein-associated extracellular aldehydes are formed by the oxidation of lysine residues on extracellular matrix proteins to form the aldehyde allysine. Here we report three Mn(II)-based, small-molecule magnetic resonance probes that contain α-effect nucleophiles to target allysine in vivo and report on tissue fibrogenesis. We used a rational design approach to develop turn-on probes with a 4-fold increase in relaxivity upon targeting.
View Article and Find Full Text PDFDuring fibroproliferation, protein-associated extracellular aldehydes are formed by the oxidation of lysine residues on extracellular matrix proteins to form the aldehyde allysine. Here we report three Mn(II)-based, small molecule magnetic resonance (MR) probes that contain α-effect nucleophiles to target allysine in vivo and report on tissue fibrogenesis. We used a rational design approach to develop turn-on probes with a 4-fold increase in relaxivity upon targeting.
View Article and Find Full Text PDF