Publications by authors named "P Pallavi Madhusoodhan"

COVID-19 has upended medical practice and education, but has also catalyzed enhancements in the field. Early on, a local group of researchers united to investigate the impact of the pandemic on pediatric hematology oncology (PHO). From this group, a regional educational series was established, "virtual-Symposium of Pediatric Hematology/Oncology of New York" (v-SYMPHONY).

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Article Synopsis
  • Pediatric oncology patients on active chemotherapy may be at increased risk for severe COVID-19, but the study found that most had mild symptoms, with 73 out of 98 positive cases being symptomatic.
  • Severe cases predominantly involved males and obese individuals, with a notable occurrence of persistent lymphopenia; however, the overall mortality rate was low, and no death was solely due to COVID-19.
  • Significant delays in cancer treatment were reported, including 67% of SARS-CoV-2 positive patients experiencing interruptions in therapy, highlighting the pandemic's substantial impact on pediatric cancer care.
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Survival of children with relapsed acute lymphoblastic leukemia is poor, and understanding mechanisms underlying resistance is essential to developing new therapy. Relapse-specific heterozygous deletions in , a crucial part of DNA mismatch repair, are frequently detected. Our aim was to determine whether deletion results in a hypermutator phenotype associated with generation of secondary mutations involved in drug resistance, or if it leads to a failure to initiate apoptosis directly in response to chemotherapeutic agents.

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Ewing sarcoma (EWS) is a primitive neuroectodermal tumor arising in bone or soft tissue. It is the second most common primary bone malignancy of children and adolescents, with a peak incidence in the second decade of life. It most often arises in the long bones of the extremities and pelvis.

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