Publications by authors named "P Pahari"

Cured-in-place-pipe (CIPP) technology has begun to be adopted for drinking water pipe repairs, and limited information exists about its drinking water quality impacts. CIPP involves the manufacture of a new plastic pipe inside a buried damaged pipe. In this study, the chemical composition of the raw materials and CIPP water quality impacts were examined.

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Article Synopsis
  • The study explores how the Omicron variant of SARS-CoV-2 enters cells by studying the spike (S) glycoprotein, which is crucial for viral fusion with the host cell membrane.
  • Researchers used advanced imaging techniques to observe the spike's conformational changes during the fusion process, finding that the S2 domain functions dynamically as a fusion machine.
  • The presence of acidic pH and calcium ions promotes significant conformational changes in the S2 domain, facilitating the irreversible fusion of the virus with the target cell membrane.
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Herein, we report pyrene-tagged amide and urea-based sugar derivatives 1 and 2 in a simple synthetic pathway to recognize I and Hg ions. Both molecules showed absorbance and fluorescence selectivity towards iodide ions in THF/HO (7/3, v/v) medium. The selectivity and sensitivity of 2 for iodide ions are superior to 1 due to more H-bond donors in 2.

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Unlabelled: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike is the fusion machine for host cell entry. Still, the mechanism by which spike protein interacts with the target lipid membrane to facilitate membrane fusion during entry is not fully understood. Here, using steady-state membrane fusion and single-molecule fluorescence resonance energy transfer imaging of spike trimers on the surface of SARS-CoV-2 pseudovirion, we directly show that spike protein interacts with phosphatidylserine (PS) lipid in the target membrane for mediating fusion.

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