Publications by authors named "P Pagano"
Article Synopsis
- - Alzheimer's Disease (AD) and related dementias are becoming a major worldwide issue due to the aging population, characterized by damage to neurological tissue and the presence of amyloid plaques and neurofibrillary tangles.
- - Recent research has focused on the role of reactive oxygen species (ROS), particularly the NADPH Oxidase 2 (NOX2) protein, which is linked to inflammation and vascular processes in the brain and plays a key role in AD development.
- - This review highlights the latest findings on how NOX2 contributes to the progression of AD and discusses promising therapies targeting NOX2 for managing and treating the disease.
Article Synopsis
- Scientists think that oxidative stress, which means damage from too many harmful substances in the body, is linked to Parkinson's disease (PD).
- A specific gene called LRRK2 has mutations that make it more active and can increase the risk of getting PD, and this is related to more oxidative stress.
- In studies with special lab techniques and cells from people with PD, it was found that blocking LRRK2 activity helps reduce harmful reactions, suggesting that controlling LRRK2 could help manage oxidative stress in PD.
Article Synopsis
- * Current vaccines help a bit but aren't very effective or safe, so scientists created a new type of vaccine using special parts of the germ.
- * The new vaccine showed good results in chickens, especially when combined with a specific ingredient that helped reduce illness and damage in their throats.
Background: Evaluation of indeterminate pulmonary nodules (IPNs) often creates a diagnostic conundrum which may delay the early detection of lung cancer. Rare circulating genetically abnormal cells (CGAC) have previously demonstrated utility as a biomarker for discriminating benign from malignant small IPNs in the LungLB assay. CGAC are identified using a unique 4-color fluorescence in-situ hybridization (FISH) assay and are thought to reflect early cell-based events in lung cancer pathogenesis and the anti-tumor immune response.
View Article and Find Full Text PDFThe United Nations forecast a significant shift in global population distribution by 2050, with rural populations projected to decline. This decline will particularly challenge mountain areas' cultural heritage, well-being, and economic sustainability. Understanding the economic, environmental, and societal effects of rural population decline is particularly important in Europe, where mountainous regions are vital for supplying goods.
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