Publications by authors named "P Paffenholz"
Introduction: Prostate cancer guidelines recommend molecular analysis of biomaterial following resistance to first-line systemic therapy in order to identify druggable mutations. We report on our results of molecular analysis of tissue specimens via next generation sequencing (NGS) in men with metastatic castration resistant prostate cancer (mCRPC).
Patients And Methods: In all, 311 mCRPC patients underwent NGS analysis from biopsy samples of progressive metastatic lesions or archival radical prostatectomy specimens.
Objectives: To reassess the role of primary retroperitoneal lymph node dissection (RPLND) in patients with marker-negative non-seminomatous germ cell tumour (NSGCT) clinical stage (CS) 2a, to explore results in patients with CS 2b and to evaluate surgical methods, recurrence, and adjuvant chemotherapy indications.
Materials And Methods: Data from 17 institutions were collected, comprising 305 men who underwent primary RPLND for CS 2 NSGCT. Regression analyses were conducted to predict histology in the RPLND specimen and disease-free survival (DFS).
Background: Lu PSMA therapy is increasingly used for metastatic castration-resistant prostate cancer (mCRPC) treatment. However, data on its efficacy and safety in patients previously treated with Ra remain limited.
Methods: This retrospective, multicenter study evaluated 233 mCRPC patients treated with Lu PSMA at 5 European centers.
Article Synopsis
- Testicular tumors mainly affect younger men, while penile cancer is more frequently seen in older men, and early detection can improve survival chances.
- Comprehensive literature review finds no general screening programs for these cancers; instead, self-examination for testicular tumors and education on risk factors for penile cancer are highlighted.
- Raising awareness and educating at-risk individuals is vital, with physicians playing a crucial role in promoting early detection strategies.
Article Synopsis
- The study aimed to identify key factors influencing the choice of surgical treatment for patients with localized Renal-Cell Carcinoma (RCC) using clinical and nephrometry data.
- It involved a retrospective analysis of patients who underwent surgery for localized RCC between 2010 and 2017 and used multivariate predictive modeling to assess risks associated with surgical options.
- Results indicated that the risks for partial nephrectomy (PN) were linked to remaining functioning kidney tissue volumes for polar and lateral tumors, while tumor size was the main factor for medial tumors, with the predictive model showing high sensitivity (95.2%) and specificity (95.4%).