Speed characteristics of speed pedelecs, pedelecs and conventional bicycles in naturalistic urban and rural traffic conditions.

To assess the potential impact of the higher speeds of pedal-assisted bicycles on safety, this study compared conventional bicycles, pedelecs and speed pedelecs (hereafter called s-pedelecs) on mean speeds, speed variability, harsh braking events (decelerations > 2 m/s), and mean speeds above the speed limit (MSAL) in rural and urban areas in the Netherlands Data were collected in daily traffic, while the legal maximum speed for speed-pedelecs was 25 km/h, and pedelecs and s-pedelecs shared the infrastructure with conventional bicycles. Data were collected, using two-wheelers equipped with accelerometers and GPS. Personality factors - sensation seeking and risk taking - were measured with surveys.

Effects of Southern Hemisphere Wind Changes on the Meridional Overturning Circulation in Ocean Models.

Observations show that the Southern Hemisphere zonal wind stress maximum has increased significantly over the past 30 years. Eddy-resolving ocean models show that the resulting increase in the Southern Ocean mean flow meridional overturning circulation (MOC) is partially compensated by an increase in the eddy MOC. This effect can be reproduced in the non-eddy-resolving ocean component of a climate model, providing the eddy parameterization coefficient is variable and not a constant.

Zfp423 binds autoregulatory sites in p19 cell culture model.

Zfp423 is a 30 zinc finger transcription factor that forms regulatory complexes with EBF family members and factors targeted by canonical signaling pathways. Zfp423 mutations produce a range of developmental abnormalities in mice and humans related to the ciliopathies. Surprisingly, computational analysis of clustered Zfp423 and partner motifs in conserved genomic sequences predicts enrichment in Zfp423 and Ebf genes.