Publications by authors named "P P de Deyn"
Background: Metabolic syndrome is associated with increased risk of dementia. Yet, findings on how longitudinal development of metabolic syndrome status affects cognition remain controversial.
Objectives: This study examines whether individuals with different changes in metabolic syndrome status differ in cognitive functioning.
Article Synopsis
- Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease linked to abnormal tau protein accumulation, and previous studies were limited in exploring rare genetic variants due to the use of genotype arrays.* -
- In this study, whole genome sequencing (WGS) on a large cohort allowed researchers to confirm known genetic loci related to PSP and discover new associations, particularly highlighting a different role for the APOE ε2 allele compared to Alzheimer's disease.* -
- The findings expand knowledge of PSP's genetic underpinnings and identify potential targets for future research into the disease's mechanisms and treatments.*
Background: Amnestic mild cognitive impairment (aMCI), considered as the prodromal stage of Alzheimer's disease, is characterized by isolated memory impairment and cerebral gray matter volume (GMV) alterations. Previous structural MRI studies in aMCI have been mainly based on univariate statistics using voxel-based morphometry.
Objective: We investigated structural network differences between aMCI patients and cognitively normal older adults by using source-based morphometry, a multivariate approach that considers the relationship between voxels of various parts of the brain.
Article Synopsis
- Alzheimer’s disease (AD) features include amyloid plaques and tau tangles, with differences in amyloid deposition noted in patients with APP duplications (APPdup) and Down syndrome (DS).
- The study highlights that while AD typically has extensive Aβ deposits in the brain, APPdup and DS-AD show more Aβ in blood vessels, particularly with shorter Aβ peptides.
- Significant differences were found in the types and locations of Aβ deposits among APPdup, DS-AD, sporadic AD cases, and controls, indicating distinct pathology linked to additional copies of the APP gene.