Publications by authors named "P P Tam"
Background/objectives: Orthostatic hypotension (OH) is highly prevalent in hospitalized patients and can lead to major consequences. The prevalence of OH among patients with stroke has also been reported to be high in in-patient cohorts. However, no previous analysis has focused exclusively on patients with hemorrhagic stroke, a group that may have a different disease profile, including a greater need for blood pressure control and surgical intervention.
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- EBV DNAemia surveillance is used to prevent post-transplant lymphoproliferative disorder (PTLD) in lung transplant recipients (LTRs), but its effectiveness in adult seropositive patients is unclear.
- A study analyzed EBV viral loads in seropositive LTRs and compared levels between those who developed PTLD and those who didn't, revealing that peak viral loads were only significantly higher after PTLD was suspected.
- The study found low positive predictive values (PPVs) for moderate (14.7%) and high-grade (33.3%) EBV DNAemia in indicating risk for future PTLD, suggesting improved diagnostic approaches are needed.
Article Synopsis
- The review investigates new regenerative medicine techniques to treat cholestatic liver fibrosis, which results from diseases like primary biliary cholangitis, leading to severe liver damage.
- Understanding how these diseases progress is essential since current treatments mainly address underlying causes rather than the fibrosis itself.
- The article highlights promising regenerative therapies like mesenchymal stem cell therapy and organoid technology, aiming to target fibrosis directly for better outcomes and potentially curative strategies.
The canonical Hippo-YAP1 signaling pathway is crucial for liver development and regeneration, but its role in repair and regeneration of intrahepatic bile duct in biliary atresia (BA) remains largely unknown. YAP1 expression in the liver tissues of patients with BA and Rhesus rotavirus-induced experimental BA mouse models were examined using quantitative reverse transcriptase-PCR and double immunofluorescence. Mouse EpCAM-expressing cell-derived liver organoids were generated and treated with Hippo-YAP1 pathway activators (Xmu-mp-1 and TRULI) or an inhibitor (Peptide17).
View Article and Find Full Text PDFIn this article, we comment on the article by Huang . The urgent development of new therapeutic strategies targeting macrophage polarization is critical in the fight against liver cancer. Tumor-associated macrophages (TAMs), primarily of the M2 subtype, are instrumental in cellular communication within the tumor microenvironment and are influenced by various signaling pathways, including the wingless/integrated (Wnt) pathway.
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