Residual Stress Distribution in Dievar Tool Steel Bars Produced by Conventional Additive Manufacturing and Rotary Swaging Processes.

The impact of manufacturing strategies on the development of residual stresses in Dievar steel is presented. Two fabrication methods were investigated: conventional ingot casting and selective laser melting as an additive manufacturing process. Subsequently, plastic deformation in the form of hot rotary swaging at 900 °C was applied.

Clonal T cell populations scarcely impair patients with rheumatic diseases: a prospective long-term follow up study.

Background: Clonal T cell populations are frequently detected in patients with rheumatic diseases. The relevance of this finding is often uncertain, as the clinical spectrum can range from being asymptomatic to T cell leukemia. Former studies suggested that certain anti-rheumatic drugs might influence the course of the clonal T cell populations.

Psychological impact of autologous hematopoietic stem cell transplantation in systemic sclerosis patients and influence of resilience.

Objective: In severe cases of systemic sclerosis (SSc), autologous hematopoietic stem cell transplantation (aHSCT) is superior compared to cyclophosphamide. But treatment related morbidity and mortality have to be considered. To date, data on major physical and psychological impacts of aHSCT are scarce.

Use of Janus kinase inhibitors before and after European Medicines Agency safety recommendations: a retrospective study.

Background: Safety recommendations for Janus kinase inhibitors (JAKi) issued by the European Medical Agency (EMA) in 2023 could potentially influence treatment patterns for rheumatoid arthritis (RA) drugs, but little is known about the impact of these recommendations in routine clinical care.

Methods: We retrospectively analyzed the German RHADAR rheumatology database for adult patients with RA and documentation of a new therapy with a JAKi, tumor necrosis factor inhibitor (TNFi), or interleukin-6 receptor inhibitor (IL-6Ri). Data were grouped into half-yearly intervals from quarter (Q)2/2020 to Q3/2023.