EXPRESSION OF PROGRAMMED CELL DEATH RECEPTOR IN ENDOMETRIAL CANCER PATIENTS WITH METABOLIC DISORDERS.

Aim: To study the expression of the programmed cell death receptor (PD-1) and its ligand (PD-L1) by immunocompetent cells in endometrial cancer patients with metabolic disorders.

Materials And Methods: Populations and subpopulations of lymphocytes were analyzed by flow cytometry. Antibodies against CD279 were used to detect PD-1 on the CD4+ and CD8+ T cells.

[The prospects for the use of chronomodulated chemo- and radiotherapy in oncology].

We have analysed the available worlds scientific literature concerning chronotherapy of malignant neoplasms of different localization. The review is focused on the results of multicenter investigations into this problem organized by the chronotherapy group in the framework of EORTC that have demonstrated a higher antiblastoma activity and improved tolerability of preparations applied in the chronomodulated regimen in comparison with the traditional treatment. Our original observations and recommendations ensuing from our many-year experience with the use of chemo- and radiotherapy of rectal and cervical cancer in the optimal time of day for the normal tissues constitute a basis for the more extensive introduction of chronobiological techniques to clinical practice.

[Immunity status in persons participating in liquidation of the effects of the accident at the Chernobyl nuclear power plant].

The time course study of the immunity status of 57 subjects who were engaged in liquidation of consequences of the catastrophe at Chernobyl NPS in May-December, 1986, has revealed a high frequency of disorders in bactericidal and digestive activities of neutrophils, as well as in the functional activity of T-lymphocytes in the peripheral blood. The incidence rate of subjects with disturbed functional activity of T-lymphocytes is significantly higher in the group of subjects with suppressed capacity of blood lymphocytes for DNA repair as compared to those with normal levels of blood lymphocyte capacity for DNA repair.