Publications by authors named "P P Quilichini"
Article Synopsis
- Myelin plasticity is essential for learning and memory in the adult brain, and any loss or alteration can impair brain function.
- In a mouse model study, researchers found that while spontaneous remyelination can occur after demyelination, the newly formed myelin often does not match the original structure, impacting cognitive function.
- The study revealed that even after remyelination, there were long-term cognitive deficits, including issues with memory and flexibility, likely due to changes in myelin in key brain areas like the medial prefrontal cortex and hippocampus.
Article Synopsis
- Cognitive deficits are a common comorbidity accompanying epilepsy, indicating that neural dynamics supporting cognitive functions are permanently changed rather than just affected by the occasional seizures.
- The study investigates how information processing—specifically storage and sharing of information—is disrupted in the hippocampus and entorhinal cortex in rats with experimental epilepsy.
- Findings suggest that the organization and timing of these cognitive functions in epilepsy are less ordered and more chaotic than in healthy controls, which may contribute to the widespread cognitive impairments seen in individuals with epilepsy.
Neuropixels probes have become a crucial tool for high-density electrophysiological recordings. Although most research involving these probes is in acute preparations, some scientific inquiries require long-term recordings in freely moving animals. Recent reports have presented prosthesis designs for chronic recordings, but some of them do not allow for probe recovery, which is desirable given their cost.
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- Neuronal survival and reconnection after a stroke are essential for recovery, influenced by the balance of excitation and inhibition in the brain.
- In the early phase of stroke, enhancing inhibition through GABA receptor modulation can help, whereas in later stages, the opposite modulation can support recovery.
- The study hypothesizes that octadecaneuropeptide (ODN), an astrocyte-derived modulator, can initially hinder recovery in acute stroke but, when used after three days, promotes motor recovery by correcting cortical excitability.
Over the past twenty years, the reuniens and rhomboid (ReRh) nuclei, which constitute the ventral midline thalamus, have received constantly growing attention. Since our first review article about the functional contributions of ReRh nuclei (Cassel et al., 2013), numerous (>80) important papers have extended anatomical knowledge, including at a developmental level, introduced new and very original electrophysiological insights on ReRh functions, and brought novel results on cognitive and non-cognitive implications of the ReRh.
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