Publications by authors named "P P Punjabi"
Aims: The left atrial appendage (LAA) produces natriuretic peptides and its removal or occlusion might increase the risk of heart failure (HF). We aimed to investigate the incidence of HF after LAA occlusion or removal (LAAO) in the Left Atrial Appendage Occlusion Study (LAAOS III).
Methods And Results: Patients (n = 4811) with atrial fibrillation (AF) and a CHADS-VASc score ≥2, who were having cardiac surgery for another indication, were randomized to undergo surgical LAAO or not.
Coronary artery disease (CAD) is a major health issue. This study focused on pericardial macrophages and small extracellular vesicles (sEVs) in CAD. The macrophages in CAD patients showed reduced expression of protective markers and unchanged levels of proinflammatory receptors.
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- - Myocardial revascularization, either through percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) surgery, effectively alleviates symptoms and enhances quality of life when paired with guideline-directed medical therapy.
- - Hybrid coronary revascularization is a combination approach that employs CABG for the left anterior descending artery (LAD) and PCI for other coronary vessels, targeting patients who are not ideal candidates for traditional CABG.
- - The procedure is best performed in a collaborative setting with a specialized heart team, focusing on complete revascularization, particularly in patients with complex multivessel coronary disease, leveraging advanced drug-eluting stents.