Publications by authors named "P P Mastroianni"
Article Synopsis
- Upper gastrointestinal bleeding (UGIB) could be a serious side effect of low-dose aspirin (LDA) use among patients with cardiovascular diseases, prompting this study to explore genetic factors related to this risk.
- The study involved a case-control design with three groups: patients with UGIB using LDA, LDA users without UGIB, and a healthy control group, analyzing specific genetic variants through interviews and blood samples.
- Findings indicated that certain genetic variants (rs2238631 and rs4807491) were linked to a significantly higher risk of UGIB in LDA users, suggesting that genetic testing could help identify individuals at greater risk and guide LDA use in the future.
Article Synopsis
- Forgerini et al. studied the impact of seven genetic variants on the risk of upper gastrointestinal bleeding related to acetylsalicylic acid use in 289 participants, finding no link between these variants and bleeding risk.
- The case-control study involved patients with upper gastrointestinal bleeding and matched controls who used low-dose acetylsalicylic acid, with DNA genotyping performed for specific genetic variants.
- Results showed no significant difference in genetic variant frequencies among low-dose users, but a notable difference was found between the case group and healthy controls for one variant, indicating a complex relationship between genetics and drug reactions.
Performance of triggers in detecting hospitalizations related to drug-induced respiratory disorders in older adults: A pilot cross-sectional study.
Clinics (Sao Paulo)
July 2024
Background: There is no gold-standard trigger for detecting drug-induced respiratory disorders, a type of Adverse Drug Event (ADE) with high morbimortality, particularly in older people.
Objective: To propose and evaluate the performance of triggers for detecting hospitalizations related to drug-induced respiratory disorders in older people.
Methods: A pilot cross-sectional study was conducted with older people (age ≥ 60) admitted to a Brazilian hospital.
Objective: To identify trigger tools applied to detect adverse drug events (ADEs) in older people and describe their utility and performance.
Methods: A systematic review was conducted in the PubMed, Lilacs, and Scopus databases (January 2024). Studies that developed, applied, or validated trigger tools and evaluated their utility and/or performance for detecting ADEs in older people were considered.
Economic burden of respiratory syncytial and parainfluenza viruses in children of upper-middle-income countries: a systematic review.
J Pediatr (Rio J)
November 2023
Objective: To identify and assess the current evidence available about the costs of managing hospitalized pediatric patients diagnosed with Respiratory Syncytial Virus (RSV) and Parainfluenza Virus Type 3 (PIV3) in upper-middle-income countries.
Methods: The authors conducted a systematic review across seven key databases from database inception to July 2022. Costs extracted were converted into 2022 International Dollars using the Purchasing Power Parity-adjusted.