JOYCE3.0: A General Protocol for the Specific Parametrization of Accurate Intramolecular Quantum Mechanically Derived Force Fields.

While the intrinsically multiscale nature of most advanced materials necessitates the use of cost-effective computational models based on classical physics, a reliable description of the structure and dynamics of their components often requires a quantum-mechanical treatment. In this work, we present JOYCE3.0, a software package for the parametrization of accurate, quantum-mechanically derived force fields (QMD-FFs).

Case Report: Androgenetic/biparental chimera with two biparental cell lines leading to placental mesenchymal dysplasia: a possible novel mechanism of formation.

Placental mesenchymal dysplasia (PMD) is a rare placental pathology that may be associated with Beckwith-Wiedemann features in the fetus and may be due to the presence of an androgenetic cell line. Many of the reported PMD cases describe the presence of a biparental and an isodisomic androgenetic cell line. The proposed mechanism of formation is by fertilization of a haploid ovum by a haploid sperm and duplication of the male pronucleus.

Strategies for early detection and detailed characterization of oral lesions and head and neck squamous cell carcinoma in Fanconi anemia patients.

Fanconi Anemia (FA) is an inherited disorder associated with profound DNA repair defects, marked by failure to thrive, congenital malformations, progressive bone marrow failure (BMF), and an increased susceptibility to cancer. Clinical manifestations of FA vary widely, with BMF and clonal evolution predominantly affecting younger individuals, while adults are more frequently presenting with solid tumors. Individuals with FA are at a 500-fold increased risk of developing head and neck squamous cell carcinoma (HNSCC), which tends to appear at a median age of 30 years, often at advanced stages with only a 57% two-year survival rate.

Building Bridges: Strategies for Achieving Gender Inclusivity in Science, Technology, and Innovation.

The Global Gender Gap Report of 2023, revealing a gender gap score of 68.4%, emphasizes the protracted nature of achieving full parity, estimating 131 years for closure. Besides, the European Gender Equality Index for 2023 shows modest improvement, yet only 2% of the population in this continent approach gender equality.

Impact of osteopathic tests on heart rate and heart rate variability: an observational study on osteopathic students.

Context: Osteopathic listening tests are diagnostic tools utilized in manual therapies, but their impact on physiological markers of the autonomic nervous system (ANS), such as heart rate (HR) and heart rate variability (HRV), remains unclear. This study examines these effects to clarify the role of listening tests within osteopathic practice.

Objectives: This study aims to evaluate the influence of osteopathic listening tests on HR and HRV markers, including the root mean square of successive differences (rMSSD) and the low-frequency/high-frequency (LF/HF) ratio, in healthy participants, and to contextualize the findings within existing osteopathic research on ANS modulation.