Phase I study of etoposide phosphate (etopophos) as a 30-minute infusion on days 1, 3, and 5.

Etoposide phophate is a phosphate ester prodrug of etoposide designed to improve the pharmaceutical characteristics of the parent compound. A Phase I dose-escalating study of etoposide phosphate was conducted concurrently at two institutions to determine its toxicity, pharmacokinetics, and maximum tolerated dose. Etoposide phosphate was administered i.

Clostridium septicum bacteremia in a patient with large granular lymphocyte leukemia.

This is the first case report of Clostridium septicum septicemia in a patient with large granular lymphocyte leukemia. C. septicum infection is highly associated with malignancy and causes a rapidly fatal enterocolitis among patients who are profoundly neutropenic.