Publications by authors named "P P Espana"
Article Synopsis
- The study investigates how effective a fourth dose of bivalent mRNA COVID-19 vaccine is for individuals over 60, especially when compared to those who have only received three doses.
- Results show that the fourth dose significantly reduces the risk of COVID-19 infection, hospitalization, and death.
- Additionally, having a history of prior COVID-19 infection lowers the risk of adverse outcomes in both groups, highlighting the importance of both vaccination and previous infections in protection against severe disease.
Background: There exists consistent empirical evidence in the literature pointing out ample heterogeneity in terms of the clinical evolution of patients with COVID-19. The identification of specific phenotypes underlying in the population might contribute towards a better understanding and characterization of the different courses of the disease. The aim of this study was to identify distinct clinical phenotypes among hospitalized patients with SARS-CoV-2 pneumonia using machine learning clustering, and to study their association with subsequent clinical outcomes as severity and mortality.
View Article and Find Full Text PDFImproved phenotyping in pneumonia is necessary to strengthen risk assessment. Via a feasible and multidimensional approach with basic parameters, we aimed to evaluate the effect of host response at admission on severity stratification in COVID-19 and community-acquired pneumonia (CAP). Three COVID-19 and one CAP multicenter cohorts including hospitalized patients were recruited.
View Article and Find Full Text PDFNewer higher valency pneumococcal conjugate vaccines (PCVs) have the potential to reduce the adult community-acquired pneumonia (CAP) burden. We describe the evolution and distribution of adult community-acquired pneumonia (CAP) serotypes in Spain, focusing on serotypes contained in the 20-valent PCV (PCV20). This was a prospective, observational study of chest X-ray (CXR)-confirmed CAP in immunocompetent adults hospitalized in one of four Spanish hospitals between November 2016 and November 2020.
View Article and Find Full Text PDFBackground: Chronic obstructive pulmonary disease (COPD) has been associated with worse clinical evolution/survival during a hospitalization for SARS-CoV2 (COVID-19). The objective of this study was to learn the situation of these patients at discharge as well as the risk of re-admission/mortality in the following 12 months.
Methods: We carried out a subanalysis of the RECOVID registry.