Publications by authors named "P P Chakrabarti"

This paper addresses the pressing issue of diabetes, which is a widespread condition affecting a huge population worldwide. As cells become less responsive to insulin or fail to produce it adequately, blood sugar levels rise. This has the potential to cause severe health complications including kidney disease, vision impairment and heart conditions.

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Here, we present a pleiotropic nanomedicine-a smart, functionalized redox buffering nanoparticle-that may be used to treat hematological diseases, associated splenic hyperplasia, and issues related to restricted erythropoiesis. With a diameter of 5-7 nm, the spherical nanomaterial is made of manganese oxide and citrate. Here, we have produced the novel nanomaterial and, using cutting-edge electron microscopic and spectroscopic techniques, extensively assessed its redox buffering potential in vitro with its structural integrity.

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Pneumonia is a dangerous disease that kills millions of children and elderly patients worldwide every year. The detection of pneumonia from a chest x-ray is perpetrated by expert radiologists. The chest x-ray is cheaper and is most often used to diagnose pneumonia.

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Article Synopsis
  • * In a study of 6000 obligate homodimeric complexes, AXXXA was found in 27,000 occurrences, while GXXXG appeared 18,000 times, mainly in obligate dimers compared to transient and heterodimers.
  • * AXXXA motifs play a key role in stabilizing the structure of proteins through specific hydrophobic interactions; replacing terminal Ala residues with Gly significantly reduces motif occurrences, suggesting its importance for protein design and therapeutic development.
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