Publications by authors named "P P Bertrand"
Pulmonary involvement in transthyretin cardiac amyloidosis: a case report.
Eur Heart J Case Rep
November 2024
Background: Amyloidosis is a systemic disorder characterized by the deposition of misfolded proteins in various organs. While cardiac transthyretin amyloidosis (ATTR) is well-recognized, pulmonary involvement is rare and often overlooked in clinical practice.
Case Summary: We present a case of severe, and ultimately fatal, cardiac and pulmonary ATTR amyloidosis in a 67-year-old male.
Separase plays a central role in chromosome separation during mitosis and in centrosome cycle. Tight control of separase activity is required to prevent unscheduled resolution of sister chromatid cohesion and centrosome aberrations, thereby preserving genome stability. In mammals, despite their disassembly in early mitosis, some nuclear envelope components possess mitotic roles, but links with separase activity remain unexplored.
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- The research focuses on creating new drug alternatives using cashew nutshell liquid (CNSL) as a source, aiming for environmentally friendly and health-focused solutions.
- A method called metathesis was used to synthesize these compounds, which were found to be non-toxic to several cell lines.
- One of the compounds showed significant effectiveness against certain parasitic diseases, with its mechanism of action linked to the inhibition of a specific enzyme (HDAC) in parasites.
Exercise-induced pulmonary hypertension: rationale for correcting pressures for flow and guide to non-invasive diagnosis.
Eur Heart J Cardiovasc Imaging
November 2024
Article Synopsis
- Exercise-induced pulmonary hypertension (exPHT) is linked to increased risks in various heart and lung diseases, with traditional definitions relying on absolute pressure cut-offs that may not accurately indicate the condition.
- Recent research highlights the mPAP over cardiac output (CO) slope, with a value over 3 mmHg/L/min, as a more reliable diagnostic tool for exPHT and its correlation with negative health outcomes.
- The review emphasizes the benefits of using non-invasive stress echocardiography to assess pulmonary haemodynamics during exercise and offers a practical approach for implementing the mPAP/CO slope measurement in clinical settings.
Article Synopsis
- This statement from the European Association of Cardiovascular Imaging (EACVI) outlines key principles for conducting clinical research in cardiovascular imaging.
- It serves as a useful guide for clinical researchers, cardiology fellows, and Ph.D. students in designing and implementing imaging protocols for clinical trials.
- While it can't substitute formal research training, it's highly recommended for anyone wanting to learn about or get involved in clinical trials related to cardiovascular imaging.