Two-level delivery systems for oral administration of peptides and proteins based on spore capsules of Lycopodium clavatum.

Two-level delivery systems (DSs) for oral administration of therapeutic proteins and peptides were developed. The first level consists of outer walls of Lycopodium clavatum spores (sporopollenin exine capsules, SECs) with included target objects; the alginate microgranules serve as the second (outer) level. Alginate (a pH-dependent natural polymer) protects peptides from gastric acidity and enzyme exposure and provides slow release of target objects in an alkaline intestinal medium.

[Cognitive dysfunction and content of inflammatory markers in patients after coronary artery bypass graft].

Aim: To study the relationship between the content of inflammatory biomarkers and cognitive function in patients after coronary artery bypass graft (CABG) performed in condition of artificial blood circulation (ABC) or open-heart surgery (OHS).

Material And Methods: Twenty-nine patients with ischemic heart disease who survived CABG, mean age 62.4±6.

[Structure and properties of extracellular proteins regulating the proteolytic phase of complement activation].

The structure and biochemical properties of the major soluble regulatory proteins of the complement, including the CI-inhibitor, factors I, H, and J, properdin, the C4-binding protein and other protein components, are reviewed. Three types of the proteolytic complement cascade regulation by proteins are envisaged: the first one involves the inhibition of complement proteases, the second one is based on proteolytic degradation of complement activation products and the third one includes the regulation of stability of complement protein complexes. The main functional role of humoral regulatory proteins consists in the limitation of the proteolytic cascade.

[Concentration-functional interrelationships in the human alternative complement activation pathway].

The dependence of the rate of human complement mediated lysis of rabbit erythrocytes on concentrations of factors B and D of the alternative pathway is characterized by saturation kinetics. At low B and D concentrations no lysis occurs until certain "threshold" concentrations of the respective factor are reached. The type of dependence of the hemolysis rates on the C3 concentration is wavelike, i.

[The action of karbogal on the complement system under model conditions and in an animal experiment].

The influence of dimethylperfluorocyclohexane (carbogal) on the hemolytic activity of human blood serum complement was studied in vitro. It has been show that different effects of carbogol on the complement depend on the serum lipid composition. Endotracheal administration of carbogal to rats results in a significant reduction of complement activity in the animal's blood.