Publications by authors named "P Ostergaard"
Article Synopsis
- The study aimed to describe a technique called DCMRL to identify central lymphatic abnormalities in patients with primary lymphatic issues and discuss the usefulness of the findings.
- Twenty-eight patients underwent dynamic MRI after gadolinium was injected into their inguinal lymph nodes, with a technical success rate of 82.1%.
- The results revealed various lymphatic pathologies, such as obstructions and leaks, and led to protocol improvements for better imaging; two patients benefited from embolization, demonstrating DCMRL's safety and effectiveness.
Article Synopsis
- The genomics era has led to the identification of the ERG gene as a new autosomal dominant predisposition factor for bone marrow failure (BMF) and hematological malignancies (HM), crucial for blood cell development and function.
- Research found several rare ERG variants associated with thrombocytopenia and various forms of HM, showing onset typically before age 40.
- Functional studies indicated that many ERG variants disrupt its role as a transcription factor, leading to ineffective blood cell production, with implications for clinical diagnosis and treatment strategies for affected patients and families.
Developmental and functional defects in the lymphatic system are responsible for primary lymphoedema (PL). PL is a chronic debilitating disease caused by increased accumulation of interstitial fluid, predisposing to inflammation, infections and fibrosis. There is no cure, only symptomatic treatment is available.
View Article and Find Full Text PDFMagnetic resonance lymphangiography: Establishing normal.
J Vasc Surg Venous Lymphat Disord
July 2024
Background: Despite an increased interest in visualizing the lymphatic vessels with magnetic resonance lymphangiography (MRL), little literature is available describing their appearance in nonlymphedematous individuals. To determine lymphatic abnormalities, an understanding of how healthy lymphatic vessels appear and behave needs to be established. Therefore, in this study, MRL of individuals without a history of lymphatic disease was performed.
View Article and Find Full Text PDFIntroduction: The lymphatic system has a pivotal role in immune homeostasis. To better understand this, we investigated the impact of Primary Lymphatic Anomalies (PLA) on lymphocyte numbers and phenotype.
Methods: The study comprised (i) a retrospective cohort: 177 PLA subjects from the National Primary Lymphatic Anomaly Register with clinical and laboratory data, and (ii) a prospective cohort: 28 patients with PLA and 20 healthy controls.