Publications by authors named "P Ostadal"
Article Synopsis
- Significant sex differences exist in heart structure and function, particularly in how pre-menopausal women’s hearts tolerate ischemia/reperfusion injury compared to men’s.
- Increased research in recent years highlights that these differences are not solely due to estrogen, and the role of mitochondria is being investigated as a contributing factor.
- Understanding these sex differences is crucial for clinical practice, especially when determining the best diagnostic and treatment strategies for ischemic heart disease.
Article Synopsis
- * Current guidelines emphasize that lower levels of low-density lipoprotein cholesterol (LDL-C) are better, advocating for early and aggressive treatment, including a variety of effective medications beyond just statins.
- * The International Lipid Expert Panel (ILEP) has published guidelines for optimizing LLT in post-ACS patients, highlighting the need for combination therapies and personalized care to improve adherence and treatment outcomes among high-risk individuals.
Cardiogenic shock (CS) is a devastating and fatal complication of acute myocardial infarction (AMI). CS can affect the pharmacokinetics and pharmacodynamics of medications. The unique properties of cangrelor make it the optimal P2Y12 inhibitor for CS-AMI, in terms of both efficacy and safety.
View Article and Find Full Text PDFBackground/aim: The study aims to describe the role of diabetes in patients with heart failure.
Methods: In all, 1052 chronic heart failure patients were included in the FARmacology and NeuroHumoral Activation (FAR NHL) multicenter prospective registry. They had ejection fraction below 50% and were on stable medication for at least 1 month.
Article Synopsis
- Percutaneous active mechanical circulatory support (MCS) devices are increasingly used for treating acute myocardial infarction-related cardiogenic shock (AMICS), but there is mixed evidence on their impact on patients' mortality rates.
- This study conducted an individual patient data meta-analysis of randomised controlled trials to assess the effect of early routine active MCS versus control treatments on 6-month all-cause mortality in AMICS patients.
- The analysis included nine studies with a total of 1114 patients and found that four trials evaluated venoarterial extracorporeal membrane oxygenation (VA-ECMO) while five focused on left ventricular unloading devices, contributing valuable insights into their effectiveness in this patient group.