Overexpression of autophagy enhancer PACER/RUBCNL in neurons accelerates disease in the SOD1 ALS mouse model.

Amyotrophic lateral sclerosis (ALS) is a debilitating and fatal paralytic disorder associated with motor neuron death. Mutant superoxide dismutase 1 (SOD1) misfolding and aggregation have been linked to familial ALS, with the accumulation of abnormal wild-type SOD1 species being also observed in postmortem tissue of sporadic ALS cases. Both wild-type and mutated SOD1 are reported to contribute to motoneuron cell death.

Grass pollen allergoids conjugated with mannan for subcutaneous and sublingual immunotherapy: a dose-finding study.

Background: Polymerized allergoids conjugated with mannan represent a novel approach of allergen immunotherapy targeting dendritic cells. In this study, we aimed to determine the optimal dose of mannan-allergoid conjugates derived from grass pollen ( and ) administered via either the subcutaneous or sublingual route.

Methods: A randomized, double-blind, placebo-controlled trial with a double-dummy design was conducted, involving 162 participants across 12 centers in Spain.

Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses.

SARS-CoV-2 and other sarbecoviruses continue to threaten humanity, highlighting the need to characterize common mechanisms of viral immune evasion for pandemic preparedness. Cytotoxic lymphocytes are vital for antiviral immunity and express NKG2D, an activating receptor conserved among mammals that recognizes infection-induced stress ligands (e.g.

Common Beans as a Source of Amino Acids and Cofactors for Collagen Biosynthesis.

Common beans ( L.) are widely consumed in diets all over the world and have a significant impact on human health. Proteins, vitamins, minerals, phytochemicals, and other micro- and macronutrients are abundant in these legumes.

Economic and financial risks of commercial tilapia cage culture in a neotropical reservoir.

The aim of this study was to analyze the financial and economic risks of tilapia cage culture across different production water volumes (m³). The production water volumes evaluated were 10 to 50 thousand m³ (Small Volume, SV), 51 to 150 thousand m³ (Medium Volume, MV), 151 to 300 thousand m³ (Large Volume, LV), and >301 thousand m³ (Extra-Large Volume, ELV). Productivity and economic data were obtained from a commercial Nile tilapia cage farm with 232 net cages installed in a neotropical reservoir, in Brazil, from 2017 to 2019.