[Effect of substance P on survival of rats after cerebral ischemia: the effect depends on behavior type].

In rats with different behaviour types in tests of "open field" and "forced swimming", influence of intraperitoneal administration of P-substance (PC) neuropeptide to survival and structural-metabolic changes in brain after double-sided ligating of carotid arteries. It was established that PC exerts different influence on stability to circulating cerebral hypoxia according to behaviour types: it increases stability in rats with passive behaviour type, decrease stability in rats with active behaviour type and does not influence on rats with middle behaviour type. Results shows the necessity of individual approach to peptide use with the view to increase stabilization to cerebral ischemia.

Delta sleep-inducing peptide as a factor increasing the content of substance P in the hypothalamus and the resistance of rats to emotional stress.

The influence of delta sleep-inducing peptide (DSIP, 60 and 120 nmole/kg, intraperitoneally) on the content of substance P (SP) in the hypothalamus of rats was studied in male rats of the August line. It was demonstrated that the administration of DSIP significantly increases the average content of SP in the hypothalamus, as well as its content in animals resistant to and predisposed to emotional stress. A daily one-time administration of DSIP before placing the rats in conditions of stress increases the content of SP in the hypothalamus which was decreased during emotional stress.

[Effects of C-terminal fragment of substance P-CP 5-11 on the activity of neurons of the dorsal raphe nucleus].

The experiments on Wistar rats showed that microinjection of C-terminal fragment of substance P-CP5-11 (1 microgram) into one of the antinociceptive system structure--dorsal raphe nucleus, caused a prolonged (24 hours of observation) analgetic effect by the hot plate test. Neuronal activity of dorsal raphe nucleus simultaneously enhanced. The CP5-11 antinociceptive activity was higher than the CP1-11 one.