Publications by authors named "P O Witteveen"

In patients with the rare adult-type granulosa cell tumors (aGCT), surgery is the primary treatment for both primary and recurrent disease. In cases of inoperable disease, systematic therapy is administered, but variable response rates and drug resistance complicate predicting the most effective therapy. Drug screen testing on patient-derived cell lines may offer a solution.

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Article Synopsis
  • The Utrecht Symptom Diary (USD) is a validated tool for assessing symptoms in cancer patients, incorporating 11 main symptoms and additional ones specific to those undergoing chemotherapy or targeted therapy.
  • A study conducted between 2012 and 2021 analyzed the effectiveness of these added symptoms in adult cancer patients receiving treatment, using a longitudinal cohort approach.
  • Results indicated that most added items were relevant and valid for this patient group, with all but one item (oral pain) demonstrating acceptable validity, highlighting the tool's comprehensive nature for monitoring treatment-related symptoms.
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Background: Response to hormonal therapy in advanced and recurrent endometrial cancer (EC) can be predicted by oestrogen and progesterone receptor immunohistochemical (ER/PR-IHC) expression, with response rates of 60% in PR-IHC > 50% cases. ER/PR-IHC can vary by tumour location and is frequently lost with tumour progression. Therefore, we explored the relationship between ER/PR-IHC expression and tumour location in EC.

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Objective: There is a continued need for improvement of second-line systemic treatment for metastatic and/or recurrent endometrial cancer.

Methods: In this phase II, open-label study, eligible patients had histologically or cytologically confirmed endometrial cancer, documented progressive disease, and a WHO performance status of ≤2. All participants received treatment with pazopanib 800 mg once daily until progression, unacceptable toxicity, or patient refusal.

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Objective: In the first part of this phase II study (NCT01164995), the combination of carboplatin and adavosertib (AZD1775) was shown to be safe and effective in patients with TP53 mutated platinum-resistant ovarian cancer (PROC). Here, we present the results of an additional safety and efficacy cohort and explore predictive biomarkers for resistance and response to this combination treatment.

Methods: This is a phase II, open-label, non-randomized study.

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