Regulation of blood pressure, natriuresis and renal thiazide/amiloride sensitivity in PPARalpha null mice.

This study evaluated the role of PPARalpha in renal function and whether PPARalpha knockout (KO) mice are hypertensive or salt-sensitive. We hypothesize that PPARalpha modulation of ion transport defines the capacity for sodium excretion (U(Na)V). PPARalpha KO and wild-type (WT) mice were placed on a normal salt (NS, 0.

Interspecies comparison of pharmacokinetic profile and bioavailability of (+/-)-gossypol in male Fischer-344 rats and male B6C3F mice.

Gossypol is a naturally occurring yellow substance in cotton plant that has male reproductive toxicity both in humans and some experimental animal species. Interspecies oral bioavailability and pharmacokinetic profile of (+/-)-gossypol were compared in male Fischer-344 rats and B6C3F mice after a 1) single intravenous dose, 2) single oral dose, and 3) 14 consecutive, daily, oral doses; all doses were 10 and 50 mg/kg rats and mice, respectively. In both species, the intravenous plasma (+/-)-gossypol concentrations showed a triexponential pattern, indicating a 3-compartment, open-model system.

Effect of Solanum erianthum aqueous leaf extract on Plasmodium berghei in mice.

The aqueous leaf extract of Solanum erianthum collected in May was administered orally to albino Swiss mice infected with Plasmodium berghei berghei. The schizontocidal activity on early infection was assessed by administering the extract of S. erianthum, chloroquine, or distilled water as single daily dose from the day of infection for 4 days.