Publications by authors named "P O Fernagut"
Parkinson's disease is characterized by the degeneration of substantia nigra pars compacta (SNc) dopaminergic neurons, leading to motor and cognitive symptoms. Numerous cellular and molecular adaptations following neurodegeneration or dopamine replacement therapy (DRT) have been described in motor networks but little is known regarding associative basal ganglia loops. This study investigated the contributions of nigrostriatal degeneration and pramipexole (PPX) on neuronal activity in the orbitofrontal cortex (OFC), frontostriatal plasticity, and markers of synaptic plasticity.
View Article and Find Full Text PDFLysosomal impairment is strongly implicated in Parkinson's disease (PD). Among the several PD-linked genes, the ATP13A2 gene, associated with the PARK9 locus, encodes a transmembrane lysosomal P5-type ATPase. Mutations in the ATP13A2 gene were primarily identified as the cause of Kufor-Rakeb syndrome (KRS), a juvenile-onset form of PD.
View Article and Find Full Text PDFThe involvement of parvalbumin (PV) interneurons in autism spectrum disorders (ASD) pathophysiology has been widely described without clearly elucidating how their dysfunctions could lead to ASD symptoms. The Cntnap2-/- mice, an ASD mouse model deficient for a major ASD susceptibility gene, display core ASD symptoms including motor stereotypies, which are directly linked to striatal dysfunction. This study reveals that striatal PV interneurons display hyperexcitability and hyperactivity in Cntnap2-/- mice, along with a reduced response in medium spiny neurons.
View Article and Find Full Text PDFArticle Synopsis
- The review outlines neuroprotection trials for multiple system atrophy (MSA), a serious neurodegenerative disease, and discusses important factors for conducting successful clinical trials, such as diagnosis and study design.
- Over 30 compounds have been evaluated in MSA trials, but only two have been successful in meeting their primary endpoint, indicating a need for better understanding of the disease.
- Current trials focus on targeting α-synuclein, a key feature of MSA, and emphasize the necessity of improving disease models, clinical measurement tools, and biomarker research to enhance future trial outcomes.
Article Synopsis
- * In a study involving 72 extubated patients from an ICU, researchers examined the relationship between sleep continuity measured by EEG and patient-reported sleep quality using the Richards-Campbell sleep questionnaire (RCSQ) and a simpler sleep numeric rating scale (sleep-NRS).
- * Results indicated a significant correlation between sleep continuity and sleep-NRS scores, whereas no correlation was found with RCSQ, suggesting that the numeric rating scale may be a more straightforward tool for assessing sleep quality in ICU patients.