Hypercalcemia associated with cancer of prostate without bony metastases.

Although hypercalcemia is sometimes found in carcinoma of the prostate with osseous metastases, it is rarely seen as a paraneoplastic manifestation of this neoplasm. We present a patient with such a tumor in whom severe hypercalcemia developed in the absence of detectable osseous metastases.

Experimental model for studies of continuous peritoneal'dialysis in uremic rabbits.

In this paper we describe an experimental model designed for studies of continuous ambulatory peritoneal dialysis (CAPD) in uremic rabbits. We preferred the study of uremic animals because it is not known whether peritoneal membrane differs between normal and uremic animals. Animals made uremic after bilateral nephrectomy could not survive on dialysis.

Studies of crystalluria in recurrent calcium lithiasis.

The authors have studied the distribution and total volumes of large and small crystals in the urine of healthy individuals and of those who form stones. Studies carried out on randomly obtained specimens were as reliable in identifying differences as were fasting specimens. Stone forming individuals had a greater number of large crystals and a greater total volume of crystals in the urine than had healthy persons.

Studies in inhibitors of calcification and levels of urine saturation with calcium salts in recurrent stone patients.

Studies have been done on patients with recurrent renal calculous disease, measuring in addition to the usual serum and urine constituents the inhibiting capacity of the urine and the activity products of calcium oxalate, octocalcium phosphate and brushite. Studies on the 24-hour urine calcium, phosphorus and uric acid and serum calcium indicate no essential differences between patients with calcium oxalate, mixed or uric acid stones and normal individuals. We were unable to demonstrate a difference in the inhibiting capacity of the urine between normal individuals and patients with calcium oxalate calculi, and levels of saturation of urine with calcium oxalate were identical in the calcium oxalate stone patients and normal individuals.

Traumatic rupture of the supramembranous urethra.

We reviewed 38 patients treated by an immediate realignment of the urethra after a traumatic rupture by urethrography, panendoscopy and clinical assessment. Of these 38 patients 19 have not required urethral dilatation for 4 years or more and 26 for 2 years or more, thus accomplishing with 1 operation satisfactory urinary tract function without stricture. We believe that an immediate repair offers the best results to patients with minimum surgical procedures insofar as the formation of strictures is concerned.