Publications by authors named "P O'Neil"

The index of biotic integrity (IBI) is an effective multi-metric tool for assessing biological integrity of aquatic ecosystems and regulating water quality based on fish community surveys. Percentages of individuals with deformity, eroded fin, lesion, and tumor (DELT) anomalies are used in IBIs as a measure of fish health, while the percentage of hybrids reflects changes in reproductive isolation. When rare, these are combined into a joint '% DELT + hybrids' metric.

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Article Synopsis
  • Type 2 diabetes (T2D) risk is notably higher among non-Hispanic black (NHB) and Hispanic individuals, and this study investigates whether genetic factors contribute to these racial disparities.
  • The research involved analyzing genetic risk scores associated with T2D pathways in a sample of 361 US adults, revealing that NHB participants exhibited higher scores for β-cell and proinsulin function, suggesting significant differences in T2D etiology among racial groups.
  • The findings indicate that impaired β-cell function is a key factor for NHB individuals, while issues such as liver dysfunction and insulin resistance are more prevalent in both NHB and Hispanic populations, potentially guiding future personalized treatment strategies for T2D.
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Rheostat positions, which can be substituted with various amino acids to tune protein function across a range of outcomes, are a developing area for advancing personalized medicine and bioengineering. Current methods cannot accurately predict which proteins contain rheostat positions or their substitution outcomes. To compare the prevalence of rheostat positions in homologs, we previously investigated their occurrence in two pyruvate kinase (PYK) isozymes.

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Objectives: Research on links between social, geographic, and cultural determinants of health has been thwarted by inadequate measures of culture. The purpose of this study was to improve the measurement of community culture, defined as shared patterns of attitudes and behaviors among people within a neighborhood that distinguish it from others, and to examine dimensions of culture, independent of socioeconomic and demographic factors, and their relationships with health.

Study Design: A survey research design with correlational analyses was used.

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Tobacco use and obesity are leading causes of preventable death in the U.S. E-cigarette use is on the rise; however, obesity prevalence among e-cigarette users is unknown.

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