Publications by authors named "P Nykanen"
Article Synopsis
- Despite growing interest in AI-CDS, there's insufficient empirical evidence on their effectiveness, highlighting the need for thorough evaluation of health information technology systems.
- Key aspects to assess include design, implementation, and the ethical prioritization of outcomes to ensure these technologies enhance human performance.
- Policymakers and decision-makers must integrate these evaluation principles into their strategies to avoid sub-optimal implementation and unintended consequences in healthcare systems.
Aims And Objectives: This study aimed to determine the reliability and validity of the RAFAELA patient classification system (PCS) for qualified and efficient nurses.
Background: The number of patients per nurse or diagnosis-based determination of nursing workload are imprecise measures that do not consider the variation in patients' care needs. Ensuring the reliability and validity of the RAFAELA is important for the efficient allocation of nursing resources.
Background: Darolutamide is a second-generation androgen receptor inhibitor approved for the treatment of nonmetastatic castration-resistant prostate cancer at a dosage of 600 mg orally twice daily.
Objective: We aimed to fully characterize the pharmacokinetic profile of darolutamide, its diastereomers, and its main active metabolite, keto-darolutamide.
Methods: Single-dose and multiple-dose pharmacokinetics of C-labeled and non-labeled darolutamide were evaluated in healthy subjects and patients with hepatic or renal impairment.
Objective: To assess the effectiveness of noninstitutional psychosocial interventions in preventing recidivism among criminal adolescents.
Method: We performed a systematic review and meta-analysis of randomized and nonrandomized controlled trials assessing the impact on recidivism among juveniles aged 12-17. The included studies had a low to medium risk of bias and were published between 2000 and 2019.
The biotransformation and excretion of darolutamide were investigated in a phase I study. Six healthy male volunteers received a single dose of 300 mg C-darolutamide as an oral solution in the fasted state. Plasma, urine, and feces samples were analyzed for mass balance evaluation by liquid scintillation counting (LSC).
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